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KMID : 1023120130110010029
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Korean Journal of Aesthetic Society
2013 Volume.11 No. 1 p.29 ~ p.34
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Anti-obese Function of Demethoxycurcumin through Suppression of Adipogenesis in 3T3-L1 Cells
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Kim Hae-Ok
Hwang Young-Il
Kim Gyo-Nam
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Abstract
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Obesity is a major health problem and it also closely associated with metabolic disorders. Adipogenesis was defined as a differentiation process of preadipocytes into adipocytes. Thus, adipogenesis is a potential target to treat or prevent obesity. Demethoxycurcumin (DCCM) has been reported to possess potent antioxidant and proapoptotic properties. However, its role in obesity prevention remains unknown. Here, we demonstrate the potential role of DCCM in 3T3-L1 cells. We found that 1-50 μM of DCCM showed no effect on the viability of 3T3-L1 preadipocytes. We also found DCCM dose-dependently inhibited adipogenesis, accompanied by reduced level of adipogenic transcriptional factors such as C/EBPβ and PPARγ. Our results implicate that the inhibitory action of DCCM is strongly linked to the reduction of C/EBPβ and PPARγ. These evidences provide useful information for the development of obesity-related nutri-cosmetics design.
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KEYWORD
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Obesity, Demethoxycurcumin, Adipogenesis, 3T3-L1, Nutri-cosmetics
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